A major pharmaceutical company in the Midwest United States came to us with a critical production challenge: keeping a broth with 5% cell solution at a uniform cold temperature—without damaging the cells. The Challenge: Traditional mechanical agitators risked damaging the cells due to excessive shear, making them unsuitable for this sensitive application. The customer needed a solution that would maintain uniform cooling while ensuring gentle movement of the cell culture. O

The GRQ Engineered Hygienic Clamp, having “raised the performance bar” for solving sealing issues and minimizing gasket intrusion, has now evolved further to address gall resistance without requiring thread lubrication, an improvement critical for applications where no lubrication is preferred, such as in the production suite. Standard materials can produce metal shavings in addition to galling when used with no lubrication, potentially contaminating the hygienic environment

Mixing is an integral part of many chemical production processes. In addition to conventional mechanical, or bladed, mixers, there is another category. Venturi-based mixers, or tank mixing eductors, are low-shear mixing devices that uses the existing energy within fluids to move and mix material instead of physically impinging on the fluid like mechanical mixers. The low shear process is also referred to as blending. One example of an application using tank mixing eductor

A bubble trap is a critical component in chromatography skids, designed to effectively degas process solutions. Chromatography is a technique used for separating different components from a mixture, and the bubble trap plays an essential role in maintaining the purity and efficiency of this process. To achieve optimal separation, the bubble trap must be crevice-free and self-draining to prevent any residuals that could contaminate subsequent cycles. Key Design Consideration

The GRQ Engineered Hygienic Clamp, after solving sealing and gasket intrusion problems for customers in all applications, has moved to the next level of performance expectations: gall resistance without the introduction of thread lubrication. The Problem Most Manufacturers Don't Fully Solve Most manufacturers provide a torque specification and then state, "values are based on lubricated threads." This is a real limitation in hygienic and sanitary applications specifically - t

Want the advanced features of a Hy-Trap, but currently have another manufacturer's bubble trap installed? Jacoby-Tarbox's Hy-Trap Hygienic Bubble Traps can be arranged to match your current process connections while incorporating most of the standard Hy-Trap features. The unit pictured is a custom bubble trap headed to a major pharma company in the Northeast US. Why Functional Equivalence Matters Switching bubble trap suppliers doesn't have to mean redesigning your skid. Beca

The bubble trap is a component of a chromatography skid that allows for the degassing of process solutions. Chromatography is the process of separating different components from a mixture or solution. Why Degassing Matters for Chromatography Entrained gas in a process fluid stream can interfere with chromatography separation - bubbles moving through the system can disrupt flow consistency and detection accuracy at exactly the stage where precise separation matters most. A bub

The Problem A well-known consumer goods company that makes liquid soap adds two different surfactants to their soap-making process. Initially, they were using a mechanical mixer in the tank, which forced them into a first-in, first-out policy rather than being able to draw fluid from every connection in the tank. The Solution Jacoby-Tarbox Hygienic In-Tank Eductors (also known as Tank Liquid Agitators, or TLAs) were recommended to move the surfactant around the tank and preve